Works研究成果

MENDEL Studyに関連する成果をまとめています

追加すべきものがある場合はお知らせ下さい。

Publications

Clin Gastroenterol Hepatol. 2021 Dec 28:S1542-3565(21)01359-8.

Novel Diagnostic Autoantibodies Against Endothelial Protein C Receptor in Patients With Ulcerative Colitis

J Crohns Colitis. 2021 Nov 9:jjab199.

Crohn's disease and early exposure to thiopurines are independent risk factors for mosaic chromosomal alterations in patients with inflammatory bowel diseases

Cell Mol Gastroenterol Hepatol. 2021 Mar 22:S2352-345X(21)00058-8

Thiopurine use during pregnancy has deleterious effects on offspring in Nudt15 ^{R138C knock-in mice}

Inflamm Bowel Dis. 2021 Jan 27:izab004.

Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease

Sci Rep. 2020 Jun 24;10(1):10236.

An Integrated Genomic and Transcriptomic Analysis Reveals Candidates of Susceptibility Genes for Crohn's Disease in Japanese Populations.

日本消化器病学会雑誌 2020;117(3):195-207

Pretreatment screening for inflammatory bowel diseases;significance and problems in genotyping of NUDT15

Inflamm Bowel Dis. 2020 Jul 17;26(8):1177-1187.

Genetic Analysis of Ulcerative Colitis in Japanese Individuals Using Population-specific SNP Array.

JGH Open. doi:10.1002/jgh3.12305

Repertoire analysis of memory T‐cell receptors in Japanese patients with inflammatory bowel disease

J Gastroenterol. 2020 Jan;55(1):67-77.

High-resolution melt analysis enables simple genotyping of complicated polymorphisms of codon 18 rendering the NUDT15 diplotype

Leukemia. 2020 Mar;34(3):882-894.

Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15^R138C knock-in mice

J Crohns Colitis. 2019 Apr 26;13(5):648-658.

A Genome-wide Association Study Identifying RAP1A as a Novel Susceptibility Gene for Crohn’s Disease in Japanese Individuals

J Gastroenterol. 2018 Sep;53(9):1065-1078.

NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study

J Gastroenterol. 2018 Feb;53(2):172-180.

Pharmacogenetics of thiopurines for inflammatory bowel disease in East Asia: prospects for clinical application of NUDT15 genotyping.

Pharmacogenomics J. 2016 Jun;16(3):280-5.

NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD.

Products

MEBRIGHT NUDT15キット

MEDICAL-QR　東北大カルテ連動アプリ(旧IBD-QR)

患者さんの端末に採血データなどを取り込めます。 動画などはYouTubeをご確認ください。 （紹介ページは旧IBD-QR時代のものです）

当グループでの研究は、臨床で活用できる形での還元を目指しており、その成果物を公開しています。

Others

Android

eCura system - Android

iPhone

eCura system - iPhone

Android

BEST-J score - Android

iPhone

BEST-J score - iPhone

東北大学病院消化器内科上部消化管グループの八田らが発表した研究成果を携帯端末用アプリとしたものです。
アプリは当グループが作成していますが、内容については各アプリ内に記されている原著論文を参照してください